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Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.

The cellular response to ionizing radiation includes induction of the early growth response 1 gene (EGR1). The present work has examined the involvement of reactive oxygen intermediates (ROIs) in this response. Exposure of human HL-525 cells, an HL-60 subclone deficient in protein kinase C-mediated...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Datta, R, Taneja, N, Sukhatme, V P, Qureshi, S A, Weichselbaum, R, Kufe, D W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46098/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8384722/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2419
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