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Prediction of dexamethasone release from PLGA microspheres prepared with polymer blends using a design of experiment approach
Hydrophobic drug release from poly (lactic-co-glycolic acid) (PLGA) microspheres typically exhibits a tri-phasic profile with a burst release phase followed by a lag phase and a secondary release phase. High burst release can be associated with adverse effects and the efficacy of the formulation can...
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| Veröffentlicht in: | Int J Pharm |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609624/ https://ncbi.nlm.nih.gov/pubmed/26325309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2015.08.089 |
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