Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

BACKGROUND: Adoptive T cell transfer (ACT) is currently under investigation for the treatment of metastatic cancer. Recent evidence suggests that the coinhibitory PD-1-PD-L1 axis plays a major role in ACT failure. We hypothesized that a new fusion receptor reverting PD-1–mediated inhibition into CD2...

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Publicat a:J Natl Cancer Inst
Autors principals: Kobold, Sebastian, Grassmann, Simon, Chaloupka, Michael, Lampert, Christopher, Wenk, Susanne, Kraus, Fabian, Rapp, Moritz, Düwell, Peter, Zeng, Yi, Schmollinger, Jan C., Schnurr, Max, Endres, Stefan, Rothenfußer, Simon
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609553/
https://ncbi.nlm.nih.gov/pubmed/26105028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv146
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