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A single bifunctional enzyme, PilD, catalyzes cleavage and N-methylation of proteins belonging to the type IV pilin family.

Precursors of the type IV pilins of a number of bacterial pathogens, as well as related proteins involved in extracellular protein export and DNA uptake, are synthesized with short basic leader sequences. Maturation of these proteins involves two consecutive posttranslational modifications. The lead...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Strom, M S, Nunn, D N, Lory, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46095/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8096341/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2404
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