Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum

The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-aminoquinolines known and remains effective against chloroquine-resistant parasites, but toxicit...

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Veröffentlicht in:PLoS One
Hauptverfasser: Rajapakse, Chandima S. K., Lisai, Maryna, Deregnaucourt, Christiane, Sinou, Véronique, Latour, Christine, Roy, Dipankar, Schrével, Joseph, Sánchez-Delgado, Roberto A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608832/
https://ncbi.nlm.nih.gov/pubmed/26473363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140878
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