Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease

During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles and reduce its surface area and volume. Here we show this involves a novel process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. Cell surface PS is a well-...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mankelow, Tosti J., Griffiths, Rebecca E., Trompeter, Sara, Flatt, Joanna F., Cogan, Nicola M., Massey, Edwin J., Anstee, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608391/
https://ncbi.nlm.nih.gov/pubmed/26276668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-637702
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