Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor.

An IgG3 monoclonal antibody, 6-19, derived from unmanipulated MRL/MpJ-lpr/lpr mice, exhibiting cryoglobulin and anti-IgG2a rheumatoid factor activities, induces skin leukocytoclastic vasculitis and glomerulonephritis when injected into normal mice. To determine the role of the gamma 3 heavy chain co...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Fulpius, T, Spertini, F, Reininger, L, Izui, S
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46083/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460145/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2345
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