Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

BACKGROUND: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomy...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Kiermayer, Claudia, Northrup, Emily, Schrewe, Anja, Walch, Axel, de Angelis, Martin Hrabe, Schoensiegel, Frank, Zischka, Hans, Prehn, Cornelia, Adamski, Jerzy, Bekeredjian, Raffi, Ivandic, Boris, Kupatt, Christian, Brielmeier, Markus
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608093/
https://ncbi.nlm.nih.gov/pubmed/26199228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002153
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