Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10 % of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45 % and 70 %. Numer...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Hall, Jacob B., Cooke Bailey, Jessica N., Hoffman, Joshua D., Pericak-Vance, Margaret A., Scott, William K., Kovach, Jaclyn L., Schwartz, Stephen G., Agarwal, Anita, Brantley, Milam A., Haines, Jonathan L., Bush, William S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606903/
https://ncbi.nlm.nih.gov/pubmed/26467978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0760-4
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