Type 2 Iodothyronine Deiodinase Activity Is Required for Rapid Stimulation of PI3K by Thyroxine in Human Umbilical Vein Endothelial Cells

Thyroid hormones (THs) exert a number of physiological effects on the cardiovascular system. Some of the nongenomic actions of T(3) are achieved by cross coupling the TH receptor (TR) with the phosphatidylinositol 3-kinase (PI3K)/protein kinase Akt (Akt) pathway. We observed that both T(3) and T(4)...

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Publicado en:Endocrinology
Autores principales: Aoki, Tomoyuki, Tsunekawa, Katsuhiko, Araki, Osamu, Ogiwara, Takayuki, Nara, Makoto, Sumino, Hiroyuki, Kimura, Takao, Murakami, Masami
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606755/
https://ncbi.nlm.nih.gov/pubmed/26284425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1988
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