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The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks
The first step of homology-dependent repair of DNA double-strand breaks (DSBs) is the resection of the 5′ strand to generate 3′ ss-DNA. Of the two major nucleases responsible for resection, EXO1 has intrinsic 5′->3′ directionality, but DNA2 does not. DNA2 acts with RecQ helicases such as the Wern...
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| Udgivet i: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605295/ https://ncbi.nlm.nih.gov/pubmed/26227969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv764 |
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