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An internal pilot design for prospective cancer screening trials with unknown disease prevalence

BACKGROUND: For studies that compare the diagnostic accuracy of two screening tests, the sample size depends on the prevalence of disease in the study population, and on the variance of the outcome. Both parameters may be unknown during the design stage, which makes finding an accurate sample size d...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Brinton, John T., Ringham, Brandy M., Glueck, Deborah H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604650/
https://ncbi.nlm.nih.gov/pubmed/26463684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0951-3
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