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Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups
[Image: see text] A family of cyclic 1-deoxysphingolipid derivatives of structure 4 has been designed and synthesized, which may serve as tumorigenesis suppressors for various cancers. Compound 4 is a second-generation analog developed from sphingosine (1), in which a hydroxyl substituent is moved f...
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| Publicado no: | Org Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4604444/ https://ncbi.nlm.nih.gov/pubmed/16468733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol052839v |
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