Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline

A series of novel tetracycline derivatives were synthesized with the goal of creating new antibiotics that would be unaffected by the known tetracycline resistance mechanisms. New C-9-position derivatives of minocycline (the aminomethylcyclines [AMCs]) were tested for in vitro activity against Gram-...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Honeyman, Laura, Ismail, Mohamed, Nelson, Mark L., Bhatia, Beena, Bowser, Todd E., Chen, Jackson, Mechiche, Rachid, Ohemeng, Kwasi, Verma, Atul K., Cannon, E. Pat, Macone, Ann, Tanaka, S. Ken, Levy, Stuart
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Chemistry; Biosynthesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604364/
https://ncbi.nlm.nih.gov/pubmed/26349824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01536-15
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