Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny Neurons

Transient changes in striatal dopamine (DA) concentration are considered to encode a reward prediction error (RPE) in reinforcement learning tasks. Often, a phasic DA change occurs concomitantly with a dip in striatal acetylcholine (ACh), whereas other neuromodulators, such as adenosine (Adn), chang...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Nair, Anu G., Gutierrez-Arenas, Omar, Eriksson, Olivia, Vincent, Pierre, Hellgren Kotaleski, Jeanette
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604235/
https://ncbi.nlm.nih.gov/pubmed/26468202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0730-15.2015
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