Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing

Here, we present evidence for a specific role of the splicing-related factor TCERG1 in regulating apoptosis in live cells by modulating the alternative splicing of the apoptotic genes Bcl-x and Fas. We show that TCERG1 modulates Bcl-x alternative splicing during apoptosis and its activity in Bcl-x a...

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Publicado en:PLoS One
Autores principales: Montes, Marta, Coiras, Mayte, Becerra, Soraya, Moreno-Castro, Cristina, Mateos, Elena, Majuelos, Jara, Oliver, F. Javier, Hernández-Munain, Cristina, Alcamí, José, Suñé, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604205/
https://ncbi.nlm.nih.gov/pubmed/26462236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139812
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