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Improved Safety, Bioavailability and Pharmacokinetics of Zidovudine through Lactoferrin Nanoparticles during Oral Administration in Rats

Zidovudine (AZT) is one of the most referred antiretroviral drug. In spite of its higher bioavailability (50–75%) the most important reason of its cessation are bone marrow suppression, anemia, neutropenia and various organs related toxicities. This study aims at the improvement of oral delivery of...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Kumar, Prashant, Lakshmi, Yeruva Samrajya, C., Bhaskar, Golla, Kishore, Kondapi, Anand K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604150/
https://ncbi.nlm.nih.gov/pubmed/26461917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140399
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