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Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis.

Sequence alterations in the exon 1 region of the rat c-Ki-ras gene were studied in DNA isolated from aflatoxin B1 (AFB1)-induced rat liver carcinomas and precursor lesions appearing 56 weeks after administration of the carcinogen. To detect the mutations with high sensitivity, DNA samples were analy...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Soman, N R, Wogan, G N
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46017/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.2045
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