TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection

Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarizati...

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Bibliografiske detaljer
Udgivet i:Virulence
Main Authors: Cavalla, Franco, Biguetti, Claudia Cristina, Colavite, Priscila Maria, Silveira, Elcia Varise, Martins, Walter, Letra, Ariadne, Trombone, Ana Paula Favaro, Silva, Renato Menezes, Garlet, Gustavo Pompermaier
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601384/
https://ncbi.nlm.nih.gov/pubmed/25832120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21505594.2015.1029828
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