Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding

Amyotrophic lateral sclerosis (ALS), a fatal adult-onset degenerative neuromuscular disorder with a poorly defined etiology, progresses in an orderly spatiotemporal manner from one or more foci within the nervous system, reminiscent of prion disease pathology. We have previously shown that misfolded...

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Publicado en:Prion
Autores principales: Grad, Leslie I, Pokrishevsky, Edward, Silverman, Judith M, Cashman, Neil R
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601269/
https://ncbi.nlm.nih.gov/pubmed/25551548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336896.2014.983398
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