Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

Human leukotriene C4 (LTC4) synthase was purified > 25,000-fold to homogeneity from the monocytic leukemia cell line THP-1. Beginning with taurocholate-solubilized microsomal membranes, LTC4 synthase was chromatographically resolved by (i) anion exchange, (ii) affinity chromatography (through a resi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nicholson, D W, Ali, A, Vaillancourt, J P, Calaycay, J R, Mumford, R A, Zamboni, R J, Ford-Hutchinson, A W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46011/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.2015
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