Rhesus immune responses to SIV Gag expressed by recombinant BCG vectors are independent from pre-existing mycobacterial immunity

BACKGROUND: A recombinant Mycobacterium bovis BCG (rBCG) vector expressing HIV transgenes is an attractive candidate as a dual vaccine against HIV and TB. However, pre-existing immune responses to mycobacteria may influence immune responses to rBCG. We analyzed data from a rhesus rBCG trial to deter...

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Vydáno v:Vaccine
Hlavní autoři: Korioth-Schmitz, Birgit, Perley, Casey C., Sixsmith, Jaimie D., Click, Eva M., Lee, Sunhee, Letvin, Norman L., Frothingham, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600653/
https://ncbi.nlm.nih.gov/pubmed/26192357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.07.010
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