Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase

Blastomyces adhesin-1 (BAD-1) protein mediates the virulence of the yeast Blastomyces dermatitidis, in part by binding host lung tissue, the extracellular matrix, and cellular receptors via glycosaminoglycans (GAGs), such as heparan sulfate. The tandem repeats that make up over 90% of BAD-1 appear i...

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Bibliographic Details
Published in:mBio
Main Authors: Beaussart, Audrey, Brandhorst, Tristan, Dufrêne, Yves F., Klein, Bruce S.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600121/
https://ncbi.nlm.nih.gov/pubmed/26396244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01403-15
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