Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including vascular injury, restenosis, and atherosclerosis. Ho...

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Udgivet i:PLoS One
Main Authors: Kleinhenz, Jennifer M., Murphy, Tamara C., Pokutta-Paskaleva, Anastassia P., Gleason, Rudolph L., Lyle, Alicia N., Taylor, W. Robert, Blount, Mitsi A., Cheng, Juan, Yang, Qinglin, Sutliff, Roy L., Hart, C. Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599849/
https://ncbi.nlm.nih.gov/pubmed/26451838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139756
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