Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri

Metallo-β-lactamases (MBLs) hydrolyze almost all classes of β-lactam antibiotic, including carbapenems—currently first choice drugs for opportunistic infections by Gram-negative bacterial pathogens. MBL inhibitor development is complicated by the diversity within this group of enzymes, and by the ap...

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發表在:PLoS One
Main Authors: Booth, Michael P. S., Kosmopoulou, Magda, Poirel, Laurent, Nordmann, Patrice, Spencer, James
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599830/
https://ncbi.nlm.nih.gov/pubmed/26451836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140059
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