Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells

BACKGROUND: Exposure of vascular smooth muscle cells (VSMCs) to excessive cyclic stretch such as in hypertension causes a shift in their phenotype. The focal adhesion protein zyxin can transduce such biomechanical stimuli to the nucleus of both endothelial cells and VSMCs, albeit with different thre...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Ghosh, Subhajit, Kollar, Branislav, Nahar, Taslima, Suresh Babu, Sahana, Wojtowicz, Agnieszka, Sticht, Carsten, Gretz, Norbert, Wagner, Andreas H, Korff, Thomas, Hecker, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599528/
https://ncbi.nlm.nih.gov/pubmed/26071033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001712
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