Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II–Induced Hypertension

BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)–dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. Our goal was to evaluate t...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Fry, Jessica L, Shiraishi, Yasunaga, Turcotte, Raphaël, Yu, Xunjie, Gao, Yuan Z, Akiki, Rachid, Bachschmid, Markus, Zhang, Yanhang, Morgan, Kathleen G, Cohen, Richard A, Seta, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599512/
https://ncbi.nlm.nih.gov/pubmed/26376991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002384
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