Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair

BACKGROUND: Insulin-like growth factor 1 (IGF-1) activates prosurvival pathways and improves postischemic cardiac function, but this key cytokine is not robustly expressed by cultured human cardiac stem cells. We explored the influence of an enhanced IGF-1 paracrine signature on explant-derived card...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Jackson, Robyn, Tilokee, Everad L, Latham, Nicholas, Mount, Seth, Rafatian, Ghazaleh, Strydhorst, Jared, Ye, Bin, Boodhwani, Munir, Chan, Vincent, Ruel, Marc, Ruddy, Terrence D, Suuronen, Erik J, Stewart, Duncan J, Davis, Darryl R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599498/
https://ncbi.nlm.nih.gov/pubmed/26363004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002104
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