Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction

BACKGROUND: It remains unclear whether abnormal systolic function and relaxation are essential for developing heart failure in pathophysiology of severe aortic stenosis. METHODS AND RESULTS: Yorkshire pigs underwent surgical banding of the ascending aorta. The animals were followed for up to 5 month...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Ishikawa, Kiyotake, Aguero, Jaume, Oh, Jae Gyun, Hammoudi, Nadjib, A Fish, Lauren, Leonardson, Lauren, Picatoste, Belén, Santos-Gallego, Carlos G, M. Fish, Kenneth, Hajjar, Roger J
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599422/
https://ncbi.nlm.nih.gov/pubmed/25994443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001925
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