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Post-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ

[Image: see text] Ribosomally synthesized peptides are generally limited to l-amino acid building blocks. Given the advantageous properties of peptides containing d-amino acids such as stabilization of certain turns and against proteolytic degradation, methods to introduce d-stereocenters are valuab...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Yang, Xiao, van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599312/
https://ncbi.nlm.nih.gov/pubmed/26361061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05207
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