Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

PURPOSE: PD-0332991 is a selective inhibitor of the CDK4/6 kinases with the ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar range. Here we investigate the role of CDK4/6 inhibition in human ovarian cancer. EXPERIMENTAL DESIGN: We examined the effects of PD-0332991 on prolif...

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Publicado no:Clin Cancer Res
Main Authors: Konecny, Gottfried E., Winterhoff, Boris, Kolarova, Teodora, Qi, Jingwei, Manivong, Kanthinh, Dering, Judy, Yang, Guorong, Chalukya, Meenal, Wang, He-Jing, Anderson, Lee, Kalli, Kimberly R., Finn, Richard S., Ginther, Charles, Jones, Siân, Velculescu, Victor E., Riehle, Darren, Cliby, William A., Randolph, Sophia, Koehler, Maria, Hartmann, Lynn C., Slamon, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598646/
https://ncbi.nlm.nih.gov/pubmed/21278246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2307
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