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Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation
During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative phosphoproteomics we show that Bub1 is autoph...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598568/ https://ncbi.nlm.nih.gov/pubmed/26399325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9364 |
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