Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative phosphoproteomics we show that Bub1 is autoph...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Asghar, Adeel, Lajeunesse, Audrey, Dulla, Kalyan, Combes, Guillaume, Thebault, Philippe, Nigg, Erich A., Elowe, Sabine
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598568/
https://ncbi.nlm.nih.gov/pubmed/26399325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9364
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items