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Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.

To examine the in vivo function of IgD we generated mice deficient for IgD by gene targeting. The IgD-mice show a reduced B-cell compartment with 30-50% less B cells in the spleen and lymph nodes but show a normal pre-B-cell compartment. The surface-IgD- B cells express two to three times more surfa...

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Bibliografske podrobnosti
Main Authors: Nitschke, L, Kosco, M H, Köhler, G, Lamers, M C
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC45985/
https://ncbi.nlm.nih.gov/pubmed/8446604
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