Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomatous Disease

Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granuliba...

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Bibliografski detalji
Izdano u:Infect Immun
Glavni autori: Greenberg, David E., Sturdevant, Daniel E., Marshall-Batty, Kimberly R., Chu, Jessica, Pettinato, Anthony M., Virtaneva, Kimmo, Lane, John, Geller, Bruce L., Porcella, Stephen F., Gallin, John I., Holland, Steven M., Zarember, Kol A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598409/
https://ncbi.nlm.nih.gov/pubmed/26283340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00778-15
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