Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomatous Disease

Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granuliba...

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發表在:Infect Immun
Main Authors: Greenberg, David E., Sturdevant, Daniel E., Marshall-Batty, Kimberly R., Chu, Jessica, Pettinato, Anthony M., Virtaneva, Kimmo, Lane, John, Geller, Bruce L., Porcella, Stephen F., Gallin, John I., Holland, Steven M., Zarember, Kol A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
主題:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598409/
https://ncbi.nlm.nih.gov/pubmed/26283340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00778-15
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