Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations

GsMTx4, a gating modifier peptide acting on cationic mechanosensitive channels, has a positive charge (+5 e) due to six Lys residues. The peptide does not have a stereospecific binding site on the channel but acts from the boundary lipids within a Debye length of the pore probably by changing local...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Biochim Biophys Acta
Hlavní autoři: Nishizawa, Kazuhisa, Nishizawa, Manami, Gnanasambandam, Radhakrishnan, Sachs, Frederick, Sukharev, Sergei I., Suchyna, Thomas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598310/
https://ncbi.nlm.nih.gov/pubmed/26342676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2015.09.003
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky