A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

BACKGROUND/AIM: Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2), and its associated hep...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Jung, Jin Ah, Kim, Tae-Eun, Lee, Hyun, Jeong, Byeong-Ho, Park, Hye Yun, Jeon, Kyeongman, Kwon, O Jung, Ko, Jae-Wook, Choi, Rihwa, Woo, Hye-In, Koh, Won-Jung, Lee, Soo-Youn
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598210/
https://ncbi.nlm.nih.gov/pubmed/26491254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87131
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