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Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances

Bone neoplasms, such as osteosarcoma, exhibit a propensity for systemic metastases resulting in adverse clinical outcome. Traditional treatment consisting of aggressive chemotherapy combined with surgical resection, has been the mainstay of these malignances. Therefore, bone-targeted non-toxic thera...

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Vydáno v:Biomaterials
Hlavní autoři: Segal, Ehud, Pan, Huaizhong, Benayoun, Liat, Kopečková, Pavla, Shaked, Yuval, Kopeček, Jindčrich, Satchi-Fainaro, Ronit
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598046/
https://ncbi.nlm.nih.gov/pubmed/21429572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.02.059
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