gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens

Small interfering RNAs (siRNAs) exhibit strong off-target effects, which confound the gene-level interpretation of RNA interference screens and thus limit their utility for functional genomics studies. Here, we present gespeR, a statistical model for reconstructing individual, gene-specific phenotyp...

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Gepubliceerd in:Genome Biol
Hoofdauteurs: Schmich, Fabian, Szczurek, Ewa, Kreibich, Saskia, Dilling, Sabrina, Andritschke, Daniel, Casanova, Alain, Low, Shyan Huey, Eicher, Simone, Muntwiler, Simone, Emmenlauer, Mario, Rämö, Pauli, Conde-Alvarez, Raquel, von Mering, Christian, Hardt, Wolf-Dietrich, Dehio, Christoph, Beerenwinkel, Niko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Method
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597449/
https://ncbi.nlm.nih.gov/pubmed/26445817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0783-1
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