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High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae

Meiotic recombination initiates with DNA double-strand breaks (DSBs) made by Spo11. In Saccharomyces cerevisiae, many DSBs occur in “hotspots” coinciding with nucleosome-depleted gene promoters. Transcription factors (TFs) stimulate DSB formation in some hotspots, but TF roles are complex and variab...

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Bibliographic Details
Published in:Genetics
Main Authors: Zhu, Xuan, Keeney, Scott
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596667/
https://ncbi.nlm.nih.gov/pubmed/26245832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.178293
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