Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome1,2,3

Mutations in a voltage-gated sodium channel (SCN1A) result in Dravet Syndrome (DS), a catastrophic childhood epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new d...

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Bibliographic Details
Published in:eNeuro
Main Authors: Dinday, Matthew T., Baraban, Scott C.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2015
Subjects:
New Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596025/
https://ncbi.nlm.nih.gov/pubmed/26465006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0068-15.2015
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