Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding

XAF1 is a tumour suppressor gene that compromises cell viability by modulating different cellular events such as mitosis, cell cycle progression and apoptosis. In cancer, the XAF1 gene is commonly silenced by CpG-dinucleotide hypermethylation of its promoter. DNA demethylating agents induce transcri...

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Vydáno v:Sci Rep
Hlavní autoři: Victoria-Acosta, Georgina, Vazquez-Santillan, Karla, Jimenez-Hernandez, Luis, Muñoz-Galindo, Laura, Maldonado, Vilma, Martinez-Ruiz, Gustavo Ulises, Melendez-Zajgla, Jorge
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595840/
https://ncbi.nlm.nih.gov/pubmed/26443201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14838
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