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An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo
Channelrhodopsins are light-gated cation channels that have been widely used for optogenetic stimulation of electrically excitable cells. Replacement of a glutamic acid in the central gate with a positively charged amino acid residue reverses the ion selectivity and produces chloride-conducting ChRs...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4595828/ https://ncbi.nlm.nih.gov/pubmed/26443033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14807 |
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