Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells

INTRODUCTION: Several cytotoxic anticancer drugs inhibit DNA replication and/or mitosis, while EGFR tyrosine kinase inhibitors inactivate EGFR signalling in cancer cell. Both types of anticancer drugs improve the overall survival of the patients with non-small-cell lung cancer (NSCLC), although tumo...

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Pubblicato in:PLoS One
Autori principali: Okita, Riki, Wolf, Diana, Yasuda, Koichiro, Maeda, Ai, Yukawa, Takuro, Saisho, Shinsuke, Shimizu, Katsuhiko, Yamaguchi, Yoshiyuki, Oka, Mikio, Nakayama, Eiichi, Lundqvist, Andreas, Kiessling, Rolf, Seliger, Barbara, Nakata, Masao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595469/
https://ncbi.nlm.nih.gov/pubmed/26439264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139809
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