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Precritical State Transition Dynamics in the Attractor Landscape of a Molecular Interaction Network Underlying Colorectal Tumorigenesis

From the perspective of systems science, tumorigenesis can be hypothesized as a critical transition (an abrupt shift from one state to another) between proliferative and apoptotic attractors on the state space of a molecular interaction network, for which an attractor is defined as a stable state to...

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Veröffentlicht in:PLoS One
Hauptverfasser: Chu, Hyunho, Lee, Daewon, Cho, Kwang-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595005/
https://ncbi.nlm.nih.gov/pubmed/26439385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140172
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