A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors

AIMS: Clopidogrel and angiotensin converting enzyme (ACE) inhibitors are commonly co-prescribed drugs. Clopidogrel inhibits carboxylesterase 1 (CES1), the enzyme responsible for converting prodrug ACE inhibitors (such as ramipril and perindopril) to their active metabolites. The clinical implication...

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Udgivet i:Br J Clin Pharmacol
Main Authors: Cressman, Alex M, Macdonald, Erin M, Fernandes, Kimberly A, Gomes, Tara, Paterson, J Michael, Mamdani, Muhammad M, Juurlink, David N
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
Fag:
Pharmacoepidemiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594702/
https://ncbi.nlm.nih.gov/pubmed/25980448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12682
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