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Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature

Various missense mutations in the cytoprotective protein DJ-1 cause rare forms of inherited parkinsonism. One mutation, M26I, diminishes DJ-1 protein levels in the cell but does not result in large changes in the three-dimensional structure or thermal stability of the protein. Therefore, the molecul...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Protein Sci
Päätekijät: Milkovic, Nicole M, Catazaro, Jonathan, Lin, Jiusheng, Halouska, Steven, Kizziah, James L, Basiaga, Sara, Cerny, Ronald L, Powers, Robert, Wilson, Mark A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley & Sons, Ltd 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594666/
https://ncbi.nlm.nih.gov/pubmed/26234586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2762
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