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Study of permeation and blocker binding in TMEM16A calcium-activated chloride channels

We studied the effects of mutations of positively charged amino acid residues in the pore of X. tropicalis TMEM16A calcium-activated chloride channels: K613E, K628E, K630E; R646E and R761E. The activation and deactivation kinetics were not affected, and only K613E showed a lower current density. K62...

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Bibliografski detalji
Izdano u:Channels (Austin)
Glavni autori: Reyes, JP, Huanosta-Gutiérrez, A, López-Rodríguez, A, Martínez-Torres, A
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594575/
https://ncbi.nlm.nih.gov/pubmed/25853341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2015.1027849
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