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Erp29 Attenuates Cigarette Smoke Extract–Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells

PURPOSE: Endoplasmic reticulum protein 29 (ERp29) is a novel chaperone that was recently found decreased in human retinas with AMD. Herein, we examined the effect of ERp29 on cigarette smoke–induced RPE apoptosis and tight junction disruption. METHODS: Cultured human RPE (HRPE) cells (ARPE-19) or mo...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Huang, Chuangxin, Wang, Joshua J., Jing, Guangjun, Li, Junhua, Jin, Chenjin, Yu, Qiang, Falkowski, Marek W., Zhang, Sarah X.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594532/
https://ncbi.nlm.nih.gov/pubmed/26431474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16795
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