Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Homocysteine (HCY) is a pro-inflammatory sulphur-containing redox active endogenous amino acid, which concentration increases in neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). A widely held view suggests that HCY could contribute to neurodegeneration via promotion of oxid...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Bukharaeva, Ellya, Shakirzyanova, Anastasia, Khuzakhmetova, Venera, Sitdikova, Guzel, Giniatullin, Rashid
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594498/
https://ncbi.nlm.nih.gov/pubmed/26500495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00391
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