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Domain III S4 in closed-state fast inactivation: Insights from a periodic paralysis mutation

Heterologous expression of sodium channel mutations in hypokalemic periodic paralysis reveals 2 variants on channel dysfunction. Charge-reducing mutations of voltage sensing S4 arginine residues alter channel gating as typically studied with expression in mammalian cells. These mutations also produc...

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Detalhes bibliográficos
Publicado no:Channels (Austin)
Main Authors: Groome, James R, Jurkat-Rott, Karin, Lehmann-Horn, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594372/
https://ncbi.nlm.nih.gov/pubmed/25483590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336950.2014.958924
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